Virogen抗谷胱甘肽抗體Anti-Glutathione詳細(xì)介紹

英文背景介紹：

Glutathione is a small peptide composed of three amino acids: cysteine, glutamic acid, and glycine and is present in tissues in concentrations as high as one millimolar. It contains an unusual peptide linkage between the amine group of cysteine and the carboxyl group of the glutamate side chain. Glutathione is involved in detoxification, it binds to toxins, such as heavy metals, solvents, and pesticides, and transforms them into a form that can be excreted in urine or bile. It is also an important antioxidant, helping to maintain the -SH groups of proteins in their reduced form. Chronic functional glutathione deficiency is associated with glucose 6-phosphate dehydrogenase deficiency, immune disorders, an increased incidence of malignancies, and in the case of HIV disease, probably accelerated pathogenesis of the disease. Acute manifestations of functional glutathione deficiency can be seen in those who have taken an overdosage of acetaminophen (paracetamol). This results in depletion of glutathione in the hepatocytes, leading to liver failure and death.

中文背景介紹：

谷胱甘肽是一種由三種氨基酸組成的小肽：半胱氨酸、谷氨酸和甘氨酸，存在于組織中的濃度高達(dá)一毫摩爾。它含有半胱氨酸的胺基和谷氨酸側(cè)鏈的羧基之間的不尋常的肽鍵。谷胱甘肽參與解毒，它與重金屬、溶劑和殺蟲(chóng)劑等毒素結(jié)合，并將它們轉(zhuǎn)化為可以在尿液或膽汁中排泄的形式。它也是一種重要的抗氧化劑，有助于維持蛋白質(zhì)的 -SH 基團(tuán)的還原形式。慢性功能性谷胱甘肽缺乏癥與葡萄糖6-磷酸脫氫酶缺乏癥，免疫紊亂，惡性腫瘤發(fā)病率增加有關(guān)，并且在HIV疾病的情況下，可能加速了疾病的發(fā)病機(jī)制。功能性谷胱甘肽缺乏癥的急性表現(xiàn)可見(jiàn)于服用過(guò)量對(duì)乙酰氨基酚（撲熱息痛）的患者。這導(dǎo)致肝細(xì)胞中谷胱甘肽的消耗，導(dǎo)致肝衰竭和死亡。

產(chǎn)品名稱(chēng)別名：

Glutathione antibody

GSH antibody

Oxidised glutathione antibody

Reduced glutathione antibody

產(chǎn)品貨號(hào)：101-A

產(chǎn)品品牌：Virogen

品牌代理：靶點(diǎn)科技